Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)
| Autor: | Centonze, C, Guzzetti, C, Orlando, G, Loche, S, Italian ECOS Investigators, Angeletti, C., Antoniazzi, F., Bernasconi, S., Cardinale, G. M., Caruso-Nicoletti, M., Cavallo, L., Cianfarani, S., Citro, G., De Luca, F., Della Casa, S., Di Pietro, M., Garofalo, P., Giordano, C., Greggio, N. A., Licenziati, M. R., Maghnie, M., Parpagnoli, M., Persani, L., Pesce, S., Sacco, M., Salerno &, Tafi, L. |
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| Přispěvatelé: | Centonze, C., Guzzetti, C., Orlando, G., Loche, S., Angeletti, C., Antoniazzi, F., Bernasconi, S., Cardinale, G. M., Caruso-Nicoletti, M., Cavallo, L., Cianfarani, S., Citro, G., De Luca, F., Della Casa, S., Di Pietro, M., Garofalo, P., Giordano, C., Greggio, N. A., Licenziati, M. R., Maghnie, M., Parpagnoli, M., Persani, L., Pesce, S., Sacco, M., Salerno, M., Tafi, L., Centonze C., Guzzetti C., Orlando G., Loche S., Angeletti C., Antoniazzi F., Bernasconi S., Cardinale G.M., Caruso-Nicoletti M., Cavallo L., Cianfarani S., Citro G., De Luca F., Della Casa S., Di Pietro M., Garofalo P., Giordano C., Greggio N.A., Licenziati M.R., Maghnie M., Parpagnoli M., Persani L., Pesce S., Sacco M., Salerno M., Tafi L. |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics Databases Factual Children ECOS GHD Growth hormone Short stature Endocrinology Diabetes and Metabolism Adolescent Child Cohort Studies Dwarfism Pituitary Female Growth Disorders Human Growth Hormone Humans Italy Medication Adherence Telemedicine Medical Records Systems Computerized Wearable Electronic Devices 0302 clinical medicine Endocrinology Children ECOS GHD Growth hormone Short stature Objective measurement Settore MED/38 030220 oncology & carcinogenesis Cohort Original Article Medical Records Systems medicine.symptom Cohort study medicine.medical_specialty Dwarfism 030209 endocrinology & metabolism Databases 03 medical and health sciences medicine In patient Factual business.industry Computerized Pituitary Gh treatment Observational study business |
| Zdroj: | Journal of Endocrinological Investigation |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-019-01046-1 |
| Popis: | Background: With the use of non-objective measurement, adherence to growth hormone (GH) therapy has been reported suboptimal in a large proportion of patients, and poor adherence has been shown to affect short-term growth response in patients receiving GH treatment. Objective: The Easypod™ electronic device allows objective measurement of adherence. In this study, we report 3-year prospective adherence data of the Italian cohort of naïve GH deficient (GHD) children extrapolated from the Easypod Connect Observational Study (ECOS) database. Patients and methods: Seventy-three GHD children naïve to GH treatment were included in the analysis. 22 Italian centers participated in the study. Results: Mean adherence rate was consistently above 85% across the 3-year observation period. Particularly, mean adherence was 88.5%, 86.6%, and 85.7% after 1, 2 and 3years, respectively. Mean (± SD) height-SDS increase after the first year was 0.41 (± 0.38). Conclusions: The majority of naïve GHD children starting GH treatment with Easypod maintained an adherence rate > 85% up to 3years. Easypod is a useful tool to follow-up patients’ adherence allowing timely intervention to improve optimal treatment for these patients. |
| Databáze: | OpenAIRE |
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