Imaging of carotid artery vessel wall edema using T2-weighted cardiovascular magnetic resonance

Autor: Jesper L. Honge, Steen Fjord Pedersen, Anne Yoon Krogh Grøndal Hansen, Lars Ø Bloch, Won Yong Kim, Esben Søvsø Szocska Hansen
Rok vydání: 2014
Předmět:
Swine
Angiogenesis
medicine.medical_treatment
MULTIECHO DIXON FAT
Signal-To-Noise Ratio
Balloon
Magnetic resonance angiography
chemistry.chemical_compound
Edema
IN-VIVO
Evans Blue
Medicine(all)
Radiological and Ultrasound Technology
medicine.diagnostic_test
WATER SEPARATION
CONTRAST AGENT
Carotid Arteries
PORCINE CORONARY-ARTERIES
cardiovascular system
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
FIBROUS CAP
POSITRON-EMISSION-TOMOGRAPHY
Predictive Value of Tests
Internal medicine
Angioplasty
medicine
Animals
INTRAPLAQUE HEMORRHAGE
Radiology
Nuclear Medicine and imaging
ATHEROSCLEROTIC PLAQUES
Angiology
Inflammation
business.industry
Research
Magnetic resonance imaging
Vascular System Injuries
Atherosclerosis
Disease Models
Animal
chemistry
Cardiovascular magnetic resonance
Carotid Artery Injuries
business
Angioplasty
Balloon
Magnetic Resonance Angiography
Carotid artery
HIGH-RESOLUTION
Zdroj: Bloch, L O, Hansen, A Y K G, Pedersen, S F, Honge, J L, Kim, W Y & Søvsø Szocska Hansen, E 2014, ' Imaging of carotid artery vessel wall edema using T2-weighted cardiovascular magnetic resonance ', Journal of Cardiovascular Magnetic Resonance, vol. 16, 22, pp. 22 . https://doi.org/10.1186/1532-429X-16-22
Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Popis: Background: Atherothrombosis remains a major health problem in the western world, and carotid atherosclerosis is an important contributor to embolic ischemic strokes. It remains a clinical challenge to identify rupture-prone atherosclerotic plaques before clinical events occur. Inflammation, endothelial injury and angiogenesis are features of vulnerable plaques and may all be associated with plaque edema. Therefore, vessel wall edema, which can be detected by 2D T2-weighted cardiovascular magnetic resonance (CMR), may be used as a dynamic marker of disease activity in the atherosclerotic plaque. However, 2D imaging is limited by low spatial resolution in the slice-select direction compared to 3D imaging techniques. We sought to investigate the ability of novel 3D techniques to detect edema induced in porcine carotid arteries by acute balloon injury compared to conventional 2D T2-weighted black-blood CMR.Methods: Edema was induced unilaterally by balloon overstretch injury in the carotid artery of nine pigs. Between one to seven hours (average four hours) post injury, CMR was performed using 2D T2-weighted short-tau inversion recovery (T2-STIR), 3D volumetric isotropic turbo spin echo acquisition (VISTA) and 3D T2 prepared gradient-echo (T2prep-GE). The CMR images were compared in terms of signal-to-noise ratio (SNR) and contrast-to-noise (CNR) ratio. Furthermore, the presence of vessel wall injury was validated macroscopically by means of Evans Blue dye that only enters the injured vessel wall.Results: All three imaging sequences classified the carotid arteries correctly compared to Evans Blue and all sequences demonstrated a significant increase in SNR of the injured compared to the non-injured carotid vessel wall (T2-STIR, p = 0.002; VISTA, p = 0.004; and T2prep-GE, p = 0.003). There was no significant difference between sequences regarding SNR and CNR.Conclusion: The novel 3D imaging sequences VISTA and T2prep-GE perform comparably to conventional 2D T2-STIR in terms of detecting vessel wall edema. The improved spatial coverage of these 3D sequences may facilitate visualization of vessel wall edema to enable detection and monitoring of vulnerable carotid atherosclerotic plaques.
Databáze: OpenAIRE
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