Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

Autor:	Kai Liu, Bo Liu, Gary A. Wittert, Campbell H. Thompson, Amy T. Hutchison, Leonie K. Heilbronn
Rok vydání:	2022
Předmět:	Nutrition and Dietetics Endocrinology Diabetes and Metabolism
Zdroj:	Obesity researchclinical practice.
ISSN:	1871-403X
Popis:	Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2-9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb368df541933bdf0b168c78fa24f67e https://pubmed.ncbi.nlm.nih.gov/36509678 Zobrazit plný text záznamu Full Text from ScienceDirect