Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats
Autor: | Djanan Vejselova, H. Mehtap Kutlu, Mustafa Cengiz, Adnan Ayhanci |
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Přispěvatelé: | Belirlenecek, Anadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Kutlu, Hatice Mehtap |
Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Ellagic acid Renal failure Clinical Biochemistry Biomedical Engineering D galactosamine Bioengineering Pharmacology Body weight medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound medicine Liver damage Liver injury Kidney Toxin Apoptotic markers Cell Biology medicine.disease D-GalN 030104 developmental biology medicine.anatomical_structure chemistry Original Article Oxidative stress Biotechnology |
Zdroj: | Cytotechnology. 68:1763-1770 |
ISSN: | 1573-0778 0920-9069 |
DOI: | 10.1007/s10616-015-9928-z |
Popis: | WOS: 000383495000009 PubMed ID: 26660314 d-Galactosamine (d-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. d-GalN intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. We have investigated both preventive and curative effects of ellagic acid (EA) in this study. EA treatment at a gavage dose of 20 mg/kg body weight was administered before and after intraperitoneal (i.p.) injection of d-GalN at a dose of 750 mg/kg. Tissue and blood samples of animals were collected for morphological and biochemical evaluations. Our study results suggest that EA treatment both prior to and after the toxin administration successfully altered the toxic effects on the rats. Moreover, pre-treatment of EA was more protective than post-treatment indicated by histopathological and biochemical values. In conclusion, EA treatment both before and after d-GalN intoxication could protect kidney tissues against d-GalN induced oxidative stress. Anadolu University Scientific Research Project Unit [1501F028, 2014-22] This work was supported by Anadolu University Scientific Research Project Unit (Project No: 1501F028, Ethical Committee No: 2014-22). |
Databáze: | OpenAIRE |
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