Vascular Function in Children with Low Birthweight and Its Relationship with Early Markers of Cardiovascular Risk
| Autor: | María Peral de Bruno, Rossana Chahla, María Cristina del Valle Bazan de Casella, Zulema Chaila, Claudio Joo Turoni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Leptin
Male Pediatrics medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Endocrinology Diabetes and Metabolism medicine.medical_treatment ENDOTHELIAL FUNCTION CARDIOVASCULAR RISK FACTOR Physiology Hemodynamics CHILDREN Medicina Clínica 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Vascular Stiffness Risk Factors 030225 pediatrics medicine Plethysmograph Humans LOW BIRTHWEIGHT Child reproductive and urinary physiology Adiponectin biology business.industry Insulin C-reactive protein Anthropometry Infant Low Birth Weight medicine.disease C-Reactive Protein Cardiovascular Diseases Child Preschool Pediatrics Perinatology and Child Health Arterial stiffness biology.protein Female Endothelium Vascular Medicina Critica y de Emergencia business Follow-Up Studies |
| Popis: | Low birthweight (LBW) increases the risk of developing cardiovascular diseases (CVD). Few studies have established its impact at early ages. Aims: To study endothelial function (EF) and arterial stiffness (AS) and their relationship to early markers of CVD risk in children with LBW. Methods: In children with LBW (4-6 years; n = 53), anthropometric, haemodynamic and laboratory parameters, including HOMA-IR, hs-CRP, adiponectin and leptin, were determined. EF and AS were evaluated by digital pulse plethysmography. Data were compared with a control group (n = 33). Results: In both groups, anthropometric parameters remained within normal limits. Insulin and HOMA-IR had normal values, but they were significantly augmented in LBW children. LBW children showed higher leptin and hs-CRP levels than the control group. The LBW group had decreased EF (37.5 ± 5.6%) compared with the control group (75.0 ± 11.9%; p < 0.01), however without differences in AS. In LBW children, EF was negatively correlated with waist circumference, leptin, hs-CRP and with a cumulative score of risk factors. Conclusions: LBW children display altered EF that is related to early changes in CVD risk factors. The differences found in the metabolic parameters might indicate a pro-inflammatory state. This hypothesis is also supported by the laboratory findings and the correlation between EF and the number of CVD risk factors, suggesting that very early lifestyle interventions may be needed. Fil: Joo Turoni, Claudio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Chaila, Zulema. Provincia de Tucumán. Ministerio de Salud. Hospital del Niño Jesús. Servicio de Endocrinología; Argentina Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud. Instituto de Maternidad Nuestra Señora de Las Mercedes; Argentina Fil: Bazan de Casella, María Cristina del Valle. Provincia de Tucumán. Ministerio de Salud. Hospital del Niño Jesús. Servicio de Endocrinología; Argentina Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina |
| Databáze: | OpenAIRE |
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