INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION
| Autor: | Alan L. Johnson, Jonathan L. Tilly, Aaron J. W. Hsueh, K. I. Kowalski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Ovulation
Programmed cell death medicine.medical_specialty Swine media_common.quotation_subject Follicular Atresia Luteolysis Biology Follicle Endocrinology Internal medicine medicine Animals Ovarian follicle media_common Atretic Follicle Cell Death Staining and Labeling Follicular atresia DNA medicine.disease Premature ovarian failure medicine.anatomical_structure Atresia Autoradiography Female Chickens |
| Zdroj: | Endocrinology. 129:2799-2801 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-129-5-2799 |
| Popis: | In the ovary, greater than 99% of the follicles present at birth are destined to degenerate during life. In humans, less than 400 of the more than 400,000 follicles found at puberty will eventually ovulate whereas the overwhelming majority of follicles undergo atresia. Although follicular atresia plays a critical role during the recruitment of follicles for ovulation, the exact mechanism of this process is unknown. In chicken and porcine ovaries, atretic follicles can be morphologically distinguished from their healthy counterparts of the same size. Adapting a sensitive 3'-end labeling method for DNA analysis, we identified internucleosomal cleavage of cellular DNA in atretic (but not normal) follicles of both animal species, resembling that found during programmed cell death in embryogenesis, autoimmune T-cell removal and prostate regression. The present findings provide a basis for elucidating the hormonal signals involved in the initiation of follicular atresia during follicle recruitment, reproductive aging and premature ovarian failure. |
| Databáze: | OpenAIRE |
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