Facile preparation of chitosan-dopamine-inulin aldehyde hydrogel for drug delivery application
| Autor: | Alireza Aminoroaya, Hadi Rahnama, Shahla Khalili, Saied Nouri Khorasani, Alireza Allafchian, Mohammad Reza Molavian |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Thermogravimetric analysis
Dopamine Indomethacin macromolecular substances 02 engineering and technology Biochemistry Chitosan Mice 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems Differential scanning calorimetry Structural Biology Spectroscopy Fourier Transform Infrared medicine Animals MTT assay Fourier transform infrared spectroscopy Molecular Biology 030304 developmental biology 0303 health sciences Calorimetry Differential Scanning Chemistry Inulin technology industry and agriculture Hydrogels General Medicine Fibroblasts Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Thermogravimetry Drug delivery Self-healing hydrogels Microscopy Electron Scanning Swelling medicine.symptom 0210 nano-technology Porosity Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules. 185:716-724 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2021.06.199 |
| Popis: | Chitosan-based hydrogels are a suitable and versatile system for the design of localized and controlled drug delivery systems. In the current study, a hydrogel based on chitosan (CS), Dopamine (DA), and Inulin aldehyde (IA) was fabricated without the further use of catalyst or initiators. The effect of the IA contents as a crosslinking agent on the properties of the prepared hydrogel was studied. The crosslinking reaction between CS and IA was verified by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Various characteristics of the CS/DA/IA hydrogels were further assessed utilizing swelling experiment, in vitro drug release, in vitro cytotoxicity assay. The drug-loaded hydrogels represented the sustained release of Indomethacin according to the in vitro drug release test in acidic (pH = 4), basic (pH = 10) medium as well as physiological condition (pH = 7). Finally, the CS/DA/IA hydrogels exhibited appropriate cytocompatibility against the L-929 fibroblast cell line according to the direct contact MTT assay. |
| Databáze: | OpenAIRE |
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