Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
| Autor: | Yu-Ming Kang, Guo-Qing Zhu, Hong-Bao Li, Yao-Jun Sun, Juan Bai, Xiao-Jing Yu, Ning Jia, Chan-Juan Huo, Jin-Jun Liu, Ying Li, Shao-Wen Zhou, Jie Qi, Qing Su, Kai-Li Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant NF-E2-Related Factor 2 medicine.medical_treatment Physical Exertion Inflammation Toxicology medicine.disease_cause Rats Inbred WKY Antioxidants 03 medical and health sciences Norepinephrine 0302 clinical medicine Internal medicine Rats Inbred SHR medicine Animals Antihypertensive Agents Pharmacology Gene knockdown Neurotransmitter Agents business.industry FNDC5 Fibronectins Rats Oxidative Stress 030104 developmental biology Cytokine Blood pressure Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines medicine.symptom business Nucleus Oxidative stress Paraventricular Hypothalamic Nucleus Signal Transduction |
| Zdroj: | Toxicology and applied pharmacology. 394 |
| ISSN: | 1096-0333 |
| Popis: | Exercise training is one of the major non-pharmacological treatments for hypertension. However, the central mechanism by which exercise training attenuates the hypertensive responses remains unclear. Irisin is a muscle-secreted cytokine derived from fibronectin type III domain containing 5 (FNDC5) that will be released into the circulation during exercise. We hypothesized that irisin may play a role in the blood pressure regulation by exercise. To examine the hypothesis, our study investigated the effect of irisin on hypertension and its central mechanism. The study was performed in spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats. We found that intravenous injection of irisin effectively reduced blood pressure, plasma norepinephrine, paraventricular nucleus (PVN) levels of neuronal activation, oxidative stress and inflammation in SHRs. Moreover, irisin activated nuclear factor E2-related factor-2 (Nrf2) and restored the imbalance of neurotransmitters in the PVN. Our study also found PVN knockdown of Nrf2 abolished the protective effects of irisin on hypertension. These findings demonstrate irisin can improve hypertension via Nrf2-mediated antioxidant in the PVN. |
| Databáze: | OpenAIRE |
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