| Autor: |
Gayane Aghakhanyan, Alessandro Galgani, Andrea Vergallo, Francesco Lombardo, Nicola Martini, Filippo Baldacci, Gloria Tognoni, Andrea Leo, Federica Guidoccio, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Duccio Volterrani, Filippo S. Giorgi |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Neurobiology of Aging. 122:12-21 |
| ISSN: |
0197-4580 |
| DOI: |
10.1016/j.neurobiolaging.2022.11.002 |
| Popis: |
Locus Coeruleus (LC) degeneration occurs early in Alzheimer's disease (AD) and this could affect several brain regions innervated by LC noradrenergic axon terminals, as these bear neuroprotective effects and modulate neurovascular coupling/neuronal activity. We used LC-sensitive Magnetic Resonance imaging (MRI) sequences enabling LC integrity quantification, and [18F]Fluorodeoxyglucose (FDG) PET, to investigate the association of LC-MRI changes with brain glucose metabolism in cognitively impaired patients (30 amnesticMCI and 13 demented ones). Fifteen cognitively intact age-matched controls (HCs) were submitted only to LC-MRI for comparison with patients. Voxel-wise regression analyses of [18F]FDG images were conducted using the LC-MRI parameters signal intensity (LC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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