Donor Risk Index Has an Impact in Intraoperative Measure of Hepatic Artery Flow and in Clearance of Indocyanine Green: An Observational Cohort Study
| Autor: | Luis Olmedilla, J. A. Lopez-Baena, Cristina J Lisbona, Maitane I Orue-Echebarria, P. Lozano, Magdalena Salcedo, A. L. Colón, Anton I. Skaro, H. Sharma, J. Ferreiroa, E. Velasco, José Manuel Asencio, J.M. Pérez Peña, B. Díaz-Zorita, L. Rodríguez |
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| Rok vydání: | 2018 |
| Předmět: |
Indocyanine Green
Male medicine.medical_specialty medicine.medical_treatment Urology Hemodynamics Liver transplantation Cohort Studies chemistry.chemical_compound Hepatic Artery Liver Function Tests Risk Factors Germany medicine Humans Coloring Agents Aged Transplantation business.industry Graft Survival Middle Aged Tissue Donors Liver Transplantation medicine.anatomical_structure chemistry Liver Mann–Whitney U test Surgery Female Liver function Intraoperative Period business Indocyanine green Artery Cohort study |
| Zdroj: | Transplantation proceedings. 51(1) |
| ISSN: | 1873-2623 |
| Popis: | The increase in indications for liver transplantation has led to acceptance of donors with expanded criteria. The donor risk index (DRI) was validated with the aim of being a predictive model of graft survival based on donor characteristics. Intraoperative arterial hepatic flow and indocyanine green clearance (plasma clearance rate of indocyanine green [ICG-PDR]) are easily measurable variables in the intraoperative period that may be influenced by graft quality. Our aim was to analyze the influence of DRI on intraoperative liver hemodynamic alterations and on intraoperative dynamic liver function testing (ICG-PDR).This investigation was an observational study of a single-center cohort (n = 228) with prospective data collection and retrospective data analysis. Measurement of intraoperative flow was made with a VeriQ flowmeter based on measurement of transit time (MFTT). The ICG-PDR was obtained from all patients with a LiMON monitor (Pulsion Medical Systems AG, Munich, Germany). DRI was calculated using a previously validated formula. Normally distributed variables were compared using Student's t test. Otherwise, the Mann-Whitney U test or Kruskal-Wallis test was applied, depending on whether there were 2 or more comparable groups. The qualitative variables and risk measurements were analyzed using the chi-square test. P .05 was considered statistically significant.DRI score (mean ± SD) was 1.58 ± 0.31. The group with DRI1.7 (poor quality) had an intraoperative arterial flow of 234.2 ± 121.35 mL/min compared with the group having DRI1.7 (high quality), with an intraoperative arterial flow of 287.24 ± 156.84 mL/min (P = .02). The group with DRI1.70 had an ICG-PDR of 14.75 ± 6.52%/min at 60 minutes after reperfusion compared to the group with DRI 1.70, with an ICG-PDR of 16.68 ± 6.47%/min at 60 minutes after reperfusion (P = .09).Poor quality grafts have greater susceptibility to ischemia-reperfusion damage. Decreased intraoperative hepatic arterial flow may represent an increase in intrahepatic resistance early in the intraoperative period. |
| Databáze: | OpenAIRE |
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