Tumor-infiltrating CD45RO+ memory cells are associated with a favorable prognosis breast cancer

Autor: Misa Iijima, Takaaki Fujii, Yasuhiro Yanagita, Soichi Tsutsumi, Toshiki Yajima, Reina Yajima, Tomomi Fujisawa, Hiroyuki Kuwano, Takeshi Miyamoto
Rok vydání: 2015
Předmět:
0301 basic medicine
Oncology
CA15-3
medicine.medical_specialty
medicine.medical_treatment
Breast Neoplasms
chemical and pharmacologic phenomena
complex mixtures
Disease-Free Survival
03 medical and health sciences
Lymphocytes
Tumor-Infiltrating
0302 clinical medicine
Breast cancer
immune system diseases
Surgical oncology
hemic and lymphatic diseases
Internal medicine
Biomarkers
Tumor
medicine
Humans
Pharmacology (medical)
Radiology
Nuclear Medicine and imaging
Radical surgery
Aged
Retrospective Studies
Univariate analysis
Chemotherapy
business.industry
Tumor-infiltrating lymphocytes
Carcinoma
Ductal
Breast
hemic and immune systems
General Medicine
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
Lymphatic system
Lymphatic Metastasis
030220 oncology & carcinogenesis
Leukocyte Common Antigens
Female
Neoplasm Recurrence
Local
business
Zdroj: Breast Cancer. 23:668-674
ISSN: 1880-4233
1340-6868
Popis: CD45RO is a marker for memory lymphocytes. Whether CD45RO(+) tumor-infiltrating lymphocytes (TILs) prevent breast cancer recurrence is unclear.In the present study, we evaluated CD45RO expression in TILs as a predictor of prognosis in 98 patients with breast cancer who underwent radical surgery without neoadjuvant chemotherapy. Patients were classified as CD45RO(+)/TILs(High) or CD45RO(+)/TILs(Low) based on median immunohistochemistry levels.CD45RO(+)/TILs(High) were associated with smaller tumor size. The CD45RO(+)/TILs(High) group also had significantly fewer metastatic lymph nodes (P = 0.0082) and fewer peritumoral lymphatic invasions (P = 0.0284). The CD45RO(+)/TILs(High) group enjoyed longer recurrence-free survival (P = 0.0453) but not cancer-specific survival (P = 0.0640) in univariate analysis.These results suggested that CD45RO(+) effector cells may both help eradicate local tumors and prevent metastases to the lymphatic systems in breast cancer patients. High ratio of CD45RO expressing TILs was associated with recurrence-free survival improvement and a trend toward cancer-specific survival improvement in breast cancer patients.
Databáze: OpenAIRE
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