Convenient oxidation of alkylated phenols and methoxytoluenes to antifungal 1,4-benzoquinones with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) catalytic system in neutral ionic liquid
| Autor: | Sabrina Tempesta, Maurizio Barontini, Marcella Pasqualetti, Roberta Bernini, Enrico Mincione, Giancarlo Fabrizi |
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| Rok vydání: | 2006 |
| Předmět: |
Antifungal
4-benzoquinones 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]bf4 antifungal activity catalytic oxidations hydrogen peroxide/methyltrioxorhenium Tetrafluoroborate medicine.drug_class Organic Chemistry Alkylation Biochemistry Catalysis chemistry.chemical_compound chemistry Drug Discovery Ionic liquid medicine Organic chemistry Phenol Phenols Hydrogen peroxide |
| Zdroj: | Tetrahedron. 62:7733-7737 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2006.05.069 |
| Popis: | Alkylated phenol and methoxytoluene derivatives were catalytically and selectively oxidized to the corresponding 1,4-benzoquinones in good conversions and yields. Reactions were performed with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) in 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4, a neutral ionic liquid. Compounds were tested in vitro for their antifungal activity against the growth of several widespread soil fungi. Some of them were proved to be potent inhibitors of Fusarium sp. than ketoconazole, a commercially available and expensive antifungal agent. |
| Databáze: | OpenAIRE |
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