Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease

Autor:	James O. Lindsay, Lucia Macken, James R Goodhand, B. Sirwan, Louise Langmead, Nicholas M. Croft, N Tshuma, Peter M. Irving, N. Kamperidis, F. A. Chowdhury, Y. Koodun, N. Direkze, David S. Rampton
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty Multivariate analysis Anxiety Inflammatory bowel disease Sensitivity and Specificity Medication Adherence Young Adult Predictive Value of Tests Internal medicine medicine Humans Pharmacology (medical) Young adult Depression (differential diagnoses) Psychiatric Status Rating Scales Hepatology Receiver operating characteristic Thiopurine methyltransferase biology business.industry Depression Gastroenterology Area under the curve Age Factors medicine.disease Inflammatory Bowel Diseases Non adherence Hospitalization Cross-Sectional Studies Socioeconomic Factors Purines Multivariate Analysis Physical therapy biology.protein Female business Immunosuppressive Agents Follow-Up Studies
Zdroj:	Alimentary pharmacologytherapeutics. 38(9)
ISSN:	1365-2036
Popis:	Summary Background Medication non-adherence seems to be a particular problem in younger patients with inflammatory bowel disease (IBD) and has a negative impact on disease outcome. Aims To assess whether non-adherence, defined using thiopurine metabolite levels, is more common in young adults attending a transition clinic than adults with IBD and whether psychological co-morbidity is a contributing factor. We also determined the usefulness of the Modified Morisky 8-item Adherence Scale (MMAS-8) to detect non-adherence. Methods Seventy young adults [51% (36) male] and 74 [62% (46) male] adults were included. Psychological co-morbidity was assessed using the Hospital Anxiety Depression Scale (HADS) and self-reported adherence using the MMAS-8. Results Twelve percent (18/144) of the patients were non-adherent. Multivariate analysis [OR, (95% CI), P value] confirmed that being young adult [6.1 (1.7–22.5), 0.001], of lower socio-economic status [1.1 (1.0–1.1)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb24d1e50ae5836596b0e90c560d6c55 https://pubmed.ncbi.nlm.nih.gov/24099471 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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