Longitudinal survey of two serotine bat (Eptesicus serotinus) maternity colonies exposed to EBLV-1 (European Bat Lyssavirus type 1): Assessment of survival and serological status variations using capture-recapture models
| Autor: | Marie Moinet, Olivier Gimenez, F. Boue, Marine Wasniewski, Alexandre Servat, Emmanuelle Robardet, Elodie Montchâtre-Leroy, Dorothée Jouan, Christophe Borel, Florence Cliquet, Evelyne Picard-Meyer, Jacques Barrat |
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| Přispěvatelé: | Laboratoire de la rage et de la faune sauvage de Nancy (LRFSN), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Commission de Protection des Eaux, du Patrimoine, de l'Environnement, du Sous-sol et des Chiroptères de Lorraine (CPEPESC Lorraine), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
RNA viruses Physiology Myotis myotis medicine.disease_cause Pathology and Laboratory Medicine Antibodies Viral Biochemistry Geographical locations Serology Mark and recapture Seroepidemiologic Studies Immune Physiology Chiroptera Bats Medicine and Health Sciences Eptesicus serotinus Longitudinal Studies Mammals Immune System Proteins biology Animal Behavior lcsh:Public aspects of medicine Fruit Bats Eukaryota Spring Body Fluids Europe Infectious Diseases Medical Microbiology Animal Sociality Viral Pathogens Vertebrates Viruses RNA Viral France Seasons Pathogens Anatomy Research Article lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Immunology Zoology Microbiology Antibodies 03 medical and health sciences Rhabdoviridae Infections medicine Seroprevalence Animals European Union Rabies transmission Saliva Lyssavirus Microbial Pathogens Behavior [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Rabies virus Public Health Environmental and Occupational Health Organisms Biology and Life Sciences Proteins lcsh:RA1-1270 biology.organism_classification Virology Survival Analysis 030104 developmental biology Amniotes [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie People and places |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, 2017, 11 (11), pp.e0006048. ⟨10.1371/journal.pntd.0006048⟩ PLOS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (11), pp.e0006048. ⟨10.1371/journal.pntd.0006048⟩ PLoS Neglected Tropical Diseases, Vol 11, Iss 11, p e0006048 (2017) |
| ISSN: | 1935-2735 1935-2727 |
| DOI: | 10.1371/journal.pntd.0006048⟩ |
| Popis: | This study describes two longitudinal serological surveys of European Bat Lyssavirus type 1 (EBLV-1) antibodies in serotine bat (Eptesicus serotinus) maternity colonies located in the North-East of France. This species is currently considered as the main EBLV-1 reservoir. Multievent capture-recapture models were used to determine the factors influencing bat rabies transmission as this method accounts for imperfect detection and uncertainty in disease states. Considering the period of study, analyses revealed that survival and recapture probabilities were not affected by the serological status of individuals, confirming the capacity of bats to be exposed to lyssaviruses without dying. Five bats have been found with EBLV-1 RNA in the saliva at the start of the study, suggesting they were caught during virus excretion period. Among these bats, one was interestingly recaptured one year later and harbored a seropositive status. Along the survey, some others bats have been observed to both seroconvert (i.e. move from a negative to a positive serological status) and serorevert (i.e. move from a positive to a negative serological status). Peak of seroprevalence reached 34% and 70% in site A and B respectively. On one of the 2 sites, global decrease of seroprevalence was observed all along the study period nuanced by oscillation intervals of approximately 2–3 years supporting the oscillation infection dynamics hypothesized during a previous EBLV-1 study in a Myotis myotis colony. Seroprevalence were affected by significantly higher seroprevalence in summer than in spring. The maximum time observed between successive positive serological statuses of a bat demonstrated the potential persistence of neutralizing antibodies for at least 4 years. At last, EBLV-1 serological status transitions have been shown driven by age category with higher seroreversion frequencies in adults than in juvenile. Juveniles and female adults seemed indeed acting as distinct drivers of the rabies virus dynamics, hypothesis have been addressed but their exact role in the EBLV-1 transmission still need to be specified. Author summary A multi-annual survey of two serotine bat (Eptesicus serotinus) maternity colonies previously found exposed to European Bat Lyssavirus type 1 (EBLV-1) was assessed using capture-recapture methodology. The two roosting site were located in the North-East of France. Animals were trapped, banded, and blood samples were collected to study their status regarding EBLV-1 exposure. Using capture-recapture models, the authors found that seropositive status of bats did not affect the survival abilities of individuals. Seroprevalence of EBLV-1 antibodies within the study showed an oscillation interval of approximately 2–3 years and a higher evidence of contact with the virus in summer than in spring. The maximum duration observed between successive positive serological statuses in the bat population also demonstrated a survival for at least 4 years after the exposition. This study confirms the ability of bats to survive despite circulation of lyssaviruses within the colony. Bats could indeed provide a valuable key to improving human health, currently facing numerous zoonotic epidemic issues. |
| Databáze: | OpenAIRE |
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