MR and fluorescence imaging of gadobutrol-induced optical clearing of red fluorescent protein signal in an in vivo cancer model

Autor:	Natalia I. Kazachkina, Victoria V. Zherdeva, Irina G. Meerovich, Asiya N. Saydasheva, Ilya D. Solovyev, Daria K. Tuchina, Alexander P. Savitsky, Valery V. Tuchin, Alexei A. Bogdanov
Rok vydání:	2022
Předmět:	Luminescent Proteins Neoplasms Optical Imaging Organometallic Compounds Molecular Medicine Contrast Media Humans Radiology Nuclear Medicine and imaging Magnetic Resonance Imaging Spectroscopy
Zdroj:	NMR in biomedicineREFERENCES. 35(7)
ISSN:	1099-1492
Popis:	Multimodality registration of optical and MR images in the same tissue volume in vivo may be enabled by MR contrast agents with an optical clearing (OC) effect. The goals of this study were to (a) investigate the effects of clinical MR contrast agent gadobutrol (GB) and its combinations as a potential OC agent assisting in fluorescence intensity (FI) imaging in vivo and (b) evaluate MRI as a tool for imaging of topical or systemic application of GB for the purpose of OC. Subcutaneous tumor xenografts expressing red fluorescent marker protein were used as disease models. MRI was performed at 1 T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2354fd78cce44416cab5817b949bf6 https://pubmed.ncbi.nlm.nih.gov/35106848 Zobrazit plný text záznamu Plný text