The Impact of Obesity on Patient Reported Outcomes Following Stereotactic Body Radiation Therapy for Prostate Cancer
| Autor: | Thomas M. Yung, Li Rebekah Feng, Sean P. Collins, Leorey N. Saligan, Brian T. Collins, Marilyn Ayoob, Robyn A. Cyr, Malika Danner, Suy Simeng, Deepak Kumar, Siyuan Lei, Harsha Koneru, Edward Bae |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
obesity medicine.medical_specialty Urology Urinary system Urinary incontinence epic 03 medical and health sciences Prostate cancer 0302 clinical medicine Quality of life Prostate Cyberknife Internal medicine Survivorship curve cyberknife medicine 030212 general & internal medicine sbrt organ confined prostate cancer business.industry General Engineering medicine.disease bmi medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Radiation Oncology medicine.symptom business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.669 |
| Popis: | Purpose Stereotactic body radiation therapy (SBRT) delivers large radiation doses to the prostate while minimizing exposure to adjacent normal tissues. Large fraction sizes may increase the risks of functional decrements. Elderly men may be at an increased risk of these toxicities due to poor baseline function and hence limited reserve. This study describes patient-reported outcomes following SBRT for clinically localized prostate cancer in the elderly. Methods Between 2007 and 2017, 179 hormone-naive elderly patients (≥ 70 years old) and 210 patients under 70 years old with clinically localized prostate cancer were treated with 35-36.25 Gy SBRT in five fractions utilizing the CyberKnife Radiosurgical System (Accuray Inc.). Quality of life (QOL) was assessed using the Expanded Prostate Index Composite-Short Form (EPIC-26) questionnaire at baseline and at 1, 3, 6, 12, 18, 24, 30, and 36 months following the completion of treatment. EPIC scores range from 0 to 100, with lower values representing worsening symptoms. Results EPIC scores in the elderly cohort mirrored those in the younger cohort. EPIC urinary obstructive/irritative scores declined at one month post-SBRT (mean change from baseline ≥70: -7.9 |
| Databáze: | OpenAIRE |
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