Assessment of Pituitary Gonadotropin Reserve Using Luteinizing Hormone-Releasing Hormone (LRH) in States of Altered Thyroid Function
| Autor: | Larry A. Distiller, Julius Sagel, John E. Morley, Evan Oxenham |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Pituitary Function Tests Clinical Biochemistry Gonadotropin-releasing hormone Gonadotropic cell Hyperthyroidism Biochemistry Thyroid function tests Gonadotropin-Releasing Hormone Follicle-stimulating hormone Endocrinology Hypothyroidism Pituitary Gland Anterior Internal medicine medicine Humans Menstruation Disturbances medicine.diagnostic_test business.industry Biochemistry (medical) Middle Aged Pituitary Gland Gonadotropins Pituitary Female Thyroid function Gonadotropin Luteinizing hormone business hormones hormone substitutes and hormone antagonists Endocrine gland |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 40:512-515 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-40-3-512 |
| Popis: | Menstrual irregularities commonly accompany hyper- and hypofunction of the thyroid gland. Investigation of the pituitary-ovarian axis was undertaken in 14 hyperthyroid and 8 hypothyroid patients. The pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) responses to 100 mug luteinizing hormone-releasing hormone (LRH) was assessed. These responses were found to be similar to matched control groups in hyperthyroid premenopausal women with and without menstrual disturbances and in hyperthyroid men. The postmenopausal hyperthyroid women had an exaggerated LH response, although the FSH response was comparable to that of the control group. These results indicate normal pituitary LH and FSH reserve in hyperthyroidism. In hypothyroidism a gradation of gonadotropin response to LRH was found. In 2 of the patients there was an inadequate LH response in the presence of a normal FSH response. This demonstrates that in some cases of primary hypothyroidism there is limited pituitary LH reserve. |
| Databáze: | OpenAIRE |
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