Creatol, a creatinine metabolite, as a useful determinant of renal function
| Autor: | Takahiro Kanatsuna, Hiroshi Mori, Yoshio Nakamura, Kazuharu Ienaga, Koji Nakano, Manabu Sawada, Ko Nakamura, Masahiko Nakai, Motoharu Kondo, Goji Hasegawa |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Metabolite Renal function chemical and pharmacologic phenomena Urine Kidney chemistry.chemical_compound Drug Stability Molar ratio Reference Values Stress Physiological Internal medicine Medicine Humans In patient Chromatography High Pressure Liquid Creatinine business.industry Reproducibility of Results hemic and immune systems Oxygen CTL Endocrinology chemistry Solubility Calibration Chronic renal failure Kidney Failure Chronic business |
| Zdroj: | Nephron. 66(2) |
| ISSN: | 1660-8151 |
| Popis: | Analysis of creatol (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated that CTL is a useful determinant of renal function. The existence itself of serum CTL (s-CTL) could be a diagnostic sign for chronic renal failure (CRF): in all normal subjects, s-CTL was undetectable, but s-CTL was detectable in sera of all patients with CRF (s-Cr: > 2.0 mg/dl). And the s-CTL values increased in proportion to the severity of CRF in such patients. Furthermore, the molar ratio (CTL/Cr) in both urine and serum increased significantly in proportion to the severity of CRF. Our results indicated not only hyperproduction of CTL but also higher oxygen stress in patients according to the progression of CRF. The diagnostic importance of the CTL value and the CTL/Cr ratio are discussed. |
| Databáze: | OpenAIRE |
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