The effect of tumour size on ferromagnetic embolization hyperthermia in a rabbit liver tumour model
| Autor: | Paul Moroz, S. K. Jones, Bruce N. Gray |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Hyperthermia
Cancer Research Pathology medicine.medical_specialty Physiology Iron medicine.medical_treatment Radiation Dosage Models Biological Liver Neoplasms Experimental Hepatic arterial infusion Physiology (medical) medicine Animals Embolization Lagomorpha biology business.industry Rabbit (nuclear engineering) Hyperthermia Induced biology.organism_classification medicine.disease Embolization Therapeutic Tumour size Hepatocellular carcinoma Lipiodol Rabbits business medicine.drug |
| Zdroj: | International Journal of Hyperthermia. 18:129-140 |
| ISSN: | 1464-5157 0265-6736 |
| Popis: | Ferromagnetic Embolization Hyperthermia (FEH) consists of arterially embolizing tumours with ferromagnetic particles to cause hysteretic heating upon subsequent exposure to an alternating magnetic field. The objective was to determine the effect of tumour size during FEH using a rabbit liver tumour model.Thirty-three rabbits containing implanted hepatic VX2 carcinomas received a hepatic arterial infusion of ferromagnetic particles suspended in lipiodol. Following hysteretic heating, tumour and normal hepatic tissues were chemically analysed for iron content. Tumours were classed as small if their mass was less than the median mass for the whole group of subjects (2.1 g), and as large if their mass was greater than or equal to the median. To control for variability in tumour iron concentration, 13 small tumours were matched to 13 large tumours by iron concentration, and their heating characteristics compared.The heating rate in large tumours (median = 5.0 degrees C/min) was significantly greater than that in the matched small tumours (median = 2.8 degrees C/min), p = 0.006. Regression analysis determined that the slope of the heating rate vs iron concentration curve for large tumours was 1.5 times greater than that for the matched small tumours, p0.001. After cessation of heating in large tumours, there was continued heat dissipation into surrounding tissues, which led to anomalous temperature increases. There was an inverse linear relationship between tumour size and tumour iron concentration for a given dose of particles.For a given tumour iron concentration, larger tumours heat at a greater rate than small tumours, due to the poorer tissue cooling and better heat conduction in the necrotic regions of large tumours. This warrants further investigation as this finding could confer a significant advantage on FEH over other hyperthermic modalities in the treatment of hepatic malignancies. |
| Databáze: | OpenAIRE |
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