In vitro susceptibility to antimonials and amphotericin B of Leishmania infantum strains isolated from dogs in a region lacking drug selection pressure
| Autor: | Jean-Pierre Dedet, B. Oury, Laurence Lachaud, Khatima Ait-Oudhia, Francine Pratlong, Elodie Gazanion, Denis Sereno |
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| Rok vydání: | 2012 |
| Předmět: |
Drug
Canine leishmaniosis Antimony media_common.quotation_subject Antiprotozoal Agents Drug Resistance Microbiology Dogs Meglumine Amphotericin B Organometallic Compounds medicine Animals Parasite hosting Dog Diseases Leishmania infantum Amastigote media_common MON-281 Meglumine Antimoniate Dose-Response Relationship Drug General Veterinary biology Significant difference Antimony Potassium Tartrate General Medicine biology.organism_classification Virology In vitro Algeria Leishmaniasis Visceral Antimonial Parasitology Zymodeme MON-1 medicine.drug |
| Popis: | The aim of this study was to evaluate the susceptibility to anti-leishmanial agents of 24 strains isolated from dogs living in the urban area of Alger lacking drug selection pressure. Two different Leishmania infantum zymodemes, MON-1 and MON-281, were identified in these dogs. The in vitro susceptibility to the main forms of antimonial and amphotericin were assessed on promastigote and amastigote life stages in culture. The results obtained for both parasite life stages were concordant whatever the molecule tested. Moreover, our data showed that isolates belonging to the relatively rare zymodeme of L. infantum, MON-281, were less susceptible to antimony than MON-1, when at the same time there was no significant difference for amphotericin B. |
| Databáze: | OpenAIRE |
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