Chemical constituents from the leaves of Juglans mandshurica
| Autor: | Ming Shan Zheng, Da Lei Yao, Mei Jin, Chang Hao Zhang, Jong Keun Son, Jie Luo, Jiong Mo Cui, Gao Li |
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| Rok vydání: | 2014 |
| Předmět: |
biology
Plant Extracts Stereochemistry Organic Chemistry Juglans biology.organism_classification Antineoplastic Agents Phytogenic Naphthoquinone Plant Leaves HeLa chemistry.chemical_compound Juglans mandshurica chemistry Chemical constituents Drug Discovery Botany Humans Molecular Medicine Phenol K562 Cells Diarylheptanoids Tetralones |
| Zdroj: | Archives of Pharmacal Research. 38:480-484 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-014-0398-1 |
| Popis: | Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (8-11), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively. |
| Databáze: | OpenAIRE |
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