Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex
| Autor: | Guillermo Aquino-Miranda, Douglas S Engelke, Jose A Fernandez-Leon, Alexandria Goodson, Maria N Rasheed, Fabricio H Do Monte |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Neurons prefrontal cortex General Immunology and Microbiology QH301-705.5 General Neuroscience Science General Medicine electrophysiology General Biochemistry Genetics and Molecular Biology Rats memory Reward motivation Animals Medicine Rats Long-Evans Cues Biology (General) optogenetics olfactory fear |
| Zdroj: | eLife, Vol 10 (2021) |
| Popis: | The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic (PL) cortex respond to both threat- and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs. reward-approaching responses when an animals’ decision depends on previously associated memories. Using a conflict model in which male Long–Evans rats retrieve memories of shock- and food-paired cues, we observed two distinct phenotypes during conflict: (1) rats that continued to press a lever for food (Pressers) and (2) rats that exhibited a complete suppression in food seeking (Non-pressers). Single-unit recordings revealed that increased risk-taking behavior in Pressers is associated with persistent food-cue responses in PL, and reduced spontaneous activity in PL glutamatergic (PLGLUT) neurons during conflict. Activating PLGLUT neurons in Pressers attenuated food-seeking responses in a neutral context, whereas inhibiting PLGLUT neurons in Non-pressers reduced defensive responses and increased food approaching during conflict. Our results establish a causal role for PLGLUT neurons in mediating individual variability in memory-based risky decision-making by regulating threat-avoidance vs. reward-approach behaviors. |
| Databáze: | OpenAIRE |
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