Fruit consumption and the risk of bladder cancer
| Autor: | Anke Wesselius, Graham G. Giles, Bertrand Hémon, Sylvia H J Jochems, Piet A. van den Brandt, Frederik J. van Schooten, Bas Bueno-de-Mesquita, Raoul C. Reulen, Antonio Agudo, Frits H.M. van Osch, Roger L. Milne, Maria E. Goossens, Willem J.A. Witlox, Inge Huybrechts, Kar Keung Cheng, Elisabete Weiderpass, Richard T. Bryan, Emily White, Maree Brinkman, Maurice P. Zeegers |
|---|---|
| Přispěvatelé: | Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Farmacologie en Toxicologie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Urinary Bladder prospective cohort VEGETABLE CONSUMPTION DIET Cohort Studies 03 medical and health sciences 0302 clinical medicine DESIGN Risk Factors Internal medicine Epidemiology REGRESSION Humans Medicine COHORT UROTHELIAL CANCER Prospective cohort study METAANALYSIS Proportional Hazards Models Consumption (economics) Bladder cancer business.industry Proportional hazards model Smoking Hazard ratio food and beverages WOMEN fruit Middle Aged medicine.disease Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Cohort bladder cancer Female pooled analysis business Follow-Up Studies Cohort study |
| Zdroj: | International Journal of Cancer, 147(8), 2091-2100. Wiley |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow-up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85-0.99). Although in women the association with fruit consumption was most evident for higher-risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56-0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P-heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94-1.03), never smokers (HR = 0.96; 95% CI 0.88-1.05), former smokers (HR = 0.98; 95% CI 0.92-1.05) or current smokers (HR = 0.95; 95% CI 0.89-1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text