| Autor: |
Miriam E. Reyes‐Méndez, J. Manuel Herrera‐Zamora, Fernando Osuna‐Lopez, Irving S. Aguilar‐Martínez, José L. Góngora‐Alfaro, Ricardo A. Navarro‐Polanco, Enrique Sánchez‐Pastor, Eloy G. Moreno‐Galindo, Javier Alamilla |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Synapse (New York, N.Y.)REFERENCES. 77(1) |
| ISSN: |
1098-2396 |
| Popis: |
The suprachiasmatic nucleus (SCN) is the most important circadian clock in mammals. The SCN synchronizes to environmental light via the retinohypothalamic tract (RHT), which is an axon cluster derived from melanopsin-expressing intrinsic photosensitive retinal ganglion cells. Investigations on the development of the nonimage-forming pathway and the RHT are scarce. Previous studies imply that light stimulation during postnatal development is not needed to make the RHT functional at adult stages. Here, we examined the effects of light deprivation (i.e., constant darkness (DD) rearing) during postnatal development on the expression in the ventral SCN of two crucial proteins for the synchronization of circadian rhythms to light: the presynaptic vesicular glutamate transporter type 2 (vGluT2) and the GluN2B subunit of the postsynaptic NMDA receptor. We found that animals submitted to DD conditions exhibited a transitory reduction in the expression of vGluT2 (at P12-19) and of GluN2B (at P7-9) that was compensated at older stages. These findings support the hypothesis that visual stimulation during early ages is not decisive for normal development of the RHT-SCN pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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