Three Cases of Lymphocytic Infiltration of the Eyelid
| Autor: | Masako Ichishi, Keiichi Yamanaka, Akinobu Hayashi, Kyoko Sugioka, Koji Habe, Yasuko Sugimoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Erythema T cell lymphocytic infiltration of the skin lymphocytic infiltration of the eyelid Case Report Dermatology CD4+ T cell 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermis Biopsy medicine medicine.diagnostic_test business.industry Erythematous papule medicine.disease methylprednisolone medicine.anatomical_structure RL1-803 030220 oncology & carcinogenesis Eyelid medicine.symptom CD8+ T cell business Reticular Dermis Infiltration (medical) |
| Zdroj: | Dermatopathology Dermatopathology, Vol 8, Iss 18, Pp 124-129 (2021) |
| ISSN: | 2296-3529 |
| DOI: | 10.3390/dermatopathology8020018 |
| Popis: | Lymphocytic infiltration of the skin (LIS), first reported by Jessner and Kanof in 1953, is a disease of unknown etiology characterized by erythematous papules and plaques on the head, neck, and upper back and histopathological findings of a normal epidermis with underlying lymphocytic infiltration of the reticular dermis without mucin deposition. A 69-year-old man and a 21-year-old woman presented with edematous indurative erythema of the left upper eyelid. Lymphocytic infiltration of the dermis with CD4+ T cell predominance was noted on biopsy. A 68-year-old man presented with a four-year history of recurrent edematous indurative erythema of the right upper eyelid that extended up to the right cheek. Predominantly dermal infiltration of CD8+ T lymphocytes was found on biopsy. We treated all three patients with 8–16 mg of methylprednisolone daily, and the erythema and induration improved. CD4+ T cells were predominant in the acute phase (patients 1 and 2), whereas CD8+ T cells were predominant in the chronic phase (patient 3). CD8+ T cells may be involved in LIS recurrence. Lymphocytic infiltration of the eyelid may be associated with isolated circumscribed, edematous, indurative, colorless lesions that are responsive to daily low-to-middle doses of oral methylprednisolone. |
| Databáze: | OpenAIRE |
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