Impact of three different types of exercise on components of the inflammatory response
Autor: | Roy J. Shephard, Ingrid K. M. Brenner, Andrei I. Moldoveanu, P. Vasiliou, Valéria Maria Natale, P. N. Shek |
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Rok vydání: | 1999 |
Předmět: |
Adult
Male medicine.medical_specialty Physiology Pain Blood Pressure Inflammation Physical exercise Biology Body Temperature Natural killer cell Oxygen Consumption Heart Rate Internal medicine Heart rate medicine Humans Lymphocyte Count Exercise physiology Muscle Skeletal Creatine Kinase Exercise Public Health Environmental and Occupational Health Interleukin VO2 max Killer Cells Natural medicine.anatomical_structure Endocrinology biology.protein Cytokines Creatine kinase medicine.symptom |
Zdroj: | European Journal of Applied Physiology and Occupational Physiology. 80:452-460 |
ISSN: | 0301-5548 |
Popis: | It was hypothesized that muscle injury would be greater with eccentric than with all-out or prolonged exercise, and that immune changes might provide an indication that supplements the information provided by traditional markers such as creatine kinase (CK) or delayed-onset muscle soreness. Eight healthy males [mean (SE): age = 24.9 (2.3) years, maximum oxygen consumption (VO2(max)) = 43.0 (3.1) ml x kg(-1) x min(-1)] were each assigned to four experimental conditions, one at a time, using a randomized-block design: 5 min of cycle ergometer exercise at 90% VO2(max) (AO), a standard circuit-training routine (CT), 2 h cycle ergometer exercise at 60% VO2(max) (Long), or remained seated for 5 h. Blood samples were analyzed for CK, natural killer (NK) cell counts (CD3(-)/CD16(+)56(+)), cytolytic activity and plasma levels of the cytokines interleukin (IL)-6, IL-10, and tissue necrosis factor alpha (TNF-alpha). CK levels were only elevated significantly 72 h following CT. NK cell counts increased significantly during all three types of exercise, but returned to pre-exercise baseline values within 3 h of recovery. Cytolytic activity per NK cell was not significantly modified by any type of exercise. Prolonged exercise induced significant increases in plasma IL-6 and TNF-alpha. We conclude that the lack of correlation between traditional markers of muscle injury (plasma CK concentrations and muscle soreness rankings) and immune markers of the inflammatory response suggests that, for the types and intensities of exercise examined in this study, the exercise-induced inflammatory response is modified by humoral and cardiovascular correlates of exercise. |
Databáze: | OpenAIRE |
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