Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution
| Autor: | Henry Paridaens, Edith Sepulchre, Jean Marc Minon, Gentiane Haesbroek, Guillaume Pittie, Stephane Degesves, Yves Crama, Violeta Stojkovic, Sandrine Boccar, Michael Schyns, Christian Biemar, Jean Marc Senterre, Jerôme de Marchin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Early detection medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Pandemics Coronavirus Retrospective Studies Adult patients business.industry SARS-CoV-2 COVID-19 Retrospective cohort study General Medicine humanities 030220 oncology & carcinogenesis business Laboratories |
| Zdroj: | Acta Clinica Belgica |
| ISSN: | 2295-3337 |
| Popis: | The aim of this study was to identify early clinical and laboratory predictive factors of a severe coronavirus disease 2019 (COVID-19).A retrospective study was conducted on adult patients hospitalized for COVID-19 in our hospital. Diagnosis was based on a positive real-time reverse transcription-polymerase chain reaction (RT-PCR) on nasopharyngeal samples. The cohort was divided into two groups, i.e. a favorable evolution (FE) group and an unfavorable evolution (UFE) group, including intensive care unit (ICU) and deceased patients.Results: A total of 198 patients were enrolled in the study, with 138 FE (70%) and 60 UFE (30%). Older age, male gender, comorbidities and dyspnea at admission constituted significantly worse prognosis factors. Among laboratory features, lymphocyte and platelet counts as well as corrected glomerular filtration rate were significantly lower in UFE patients, while neutrophil to lymphocyte ratio, inflammation biomarkers, creatinine, aspartate aminotransferase, lactate dehydrogenase (LDH), glycemia and D-dimer were significantly higher. Procalcitonin and LDH appeared as the most accurate variables according to receiver operating characteristic curves.This Belgian study revealed clinical and laboratory features able to predict high risk of ICU requirement, or even death, at admission time. These results provide a potential tool for patient's triage in a context of pandemic. |
| Databáze: | OpenAIRE |
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