Different etiologies and prognoses of optic neuritis in demyelinating diseases
| Autor: | Takayuki Takeshita, Masashi Aoki, Toru Nakazawa, Ichiro Nakashima, Kazuo Fujihara, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Kimihiko Kaneko, Shunji Mugikura, Tetsuya Akaishi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Optic Neuritis Visual acuity Adolescent Immunology Central nervous system Vision Disorders Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy Optic neuritis Young adult Aged Retrospective Studies Aquaporin 4 business.industry Multiple sclerosis Retrospective cohort study Middle Aged Prognosis medicine.disease Dermatology Oligodendrocyte Cross-Sectional Studies medicine.anatomical_structure Neurology 030221 ophthalmology & optometry Etiology Female sense organs Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Demyelinating Diseases Follow-Up Studies |
| Zdroj: | Journal of Neuroimmunology. 299:152-157 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2016.09.007 |
| Popis: | We compared the clinical features of optic neuritis (ON) that are frequently observed in various central nervous system demyelinating diseases, including multiple sclerosis (MS), anti-aquaporin 4 (AQP4) antibody- and anti-myelin oligodendrocyte glycoprotein (MOG) autoantibody-related diseases. Almost all the AQP4-ON patients were female, whereas half of the MOG-ON patients were male. The ON-onset age was younger in MS-ON and was older in AQP4-ON. The ON-lesion detected using optic MRI in the acute phase was longer in MOG-ON and showed severe swelling and twisting. The worst visual acuity was similar between the diseases; however, the final visual acuity was significantly worse in AQP4-ON. |
| Databáze: | OpenAIRE |
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