Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma
| Autor: | Evely Cristina Figueira Silva, André Salim Khayat, Mariana Ferreira Leal, Paulo Pimentel Assumpção, Diana Mendes da Fonseca, Marília de Arruda Cardoso Smith, Rommel Rodríguez Burbano, Adriana Costa Guimarães, Láuren Cláudia Costa Raiol, Danielle Queiroz Calcagno |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research Genes myc Biology Adenocarcinoma Bioinformatics Protein expression Gastric adenocarcinoma Stomach Neoplasms Genetics medicine Humans Neoplasm Metastasis Molecular Biology Gene In Situ Hybridization Fluorescence Cause of death Aged Neoplasm Staging Chromosome Aberrations medicine.diagnostic_test digestive oral and skin physiology Gene Amplification Cancer Middle Aged medicine.disease digestive system diseases Early Gastric Cancer Cancer research Immunohistochemistry Female Brazil Fluorescence in situ hybridization |
| Zdroj: | Cancer genetics and cytogenetics. 181(1) |
| ISSN: | 0165-4608 |
| Popis: | Gastric cancer is the second leading cause of death by cancer in Brazil. Early gastric cancer represents approximately 10% of gastric cancer cases in some services of Brazil, which underscores the need for early gastric cancer diagnosis that could lead to better prognosis. There are few published studies of cytogenetic alterations in early gastric cancer. To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil. Three signals of MYC and MYC immunoreactivity were observed in all five samples, regardless of histologic type, tumor extension, or lymph nodal status. These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target. |
| Databáze: | OpenAIRE |
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