New roles for the RB tumor suppressor protein
| Autor: | Benjamin T. Spike, Kay F. Macleod, Huiping Liu, Alexandra Dirlam, Benjamin C. Dibling |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Senescence
Aging Tumor suppressor gene Retinoblastoma Apoptosis Biology medicine.disease Retinoblastoma Protein law.invention Gene Expression Regulation Neoplastic law Genetics Cancer research medicine Suppressor Gene silencing Homeostasis Humans Genes Tumor Suppressor Genes Retinoblastoma Gene Tissue homeostasis Developmental Biology |
| Zdroj: | Current opinion in geneticsdevelopment. 14(1) |
| ISSN: | 0959-437X |
| Popis: | For a gene whose existence was first postulated in 1971, was cloned in 1986 and whose functions have been extensively characterized ever since, you might be inclined to think there was not much new to report regarding the retinoblastoma tumor suppressor gene (RB) — but you would be wrong to make such an assumption. RB is still piquing our interest with several activities defined over the past year that reveal new and exciting roles for this key tumor suppressor gene. These functions include regulation of senescence through specific gene silencing mechanisms, control of developmental processes in extra-embryonic tissues, maintaining tissue homeostasis and determining survival responses to chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect