Evaluation of the substitution of poliomyelitis virus for testing virucidal activities of instrument and surface disinfection

Autor:	J, Steinmann, M, Eggers, I, Rapp, D, Todt, E, Steinmann, F H H, Brill, I, Schwebke
Rok vydání:	2022
Předmět:	Disinfection Microbiology (medical) Mice Infectious Diseases Viruses Animals Humans Peracetic Acid General Medicine Disinfectants Poliomyelitis
Zdroj:	Journal of Hospital Infection. 122:60-63
ISSN:	0195-6701
Popis:	The Global Polio Eradication initiative has the goal to eradicate poliomyelitis worldwide. This means that poliomyelitisvirus type 1 strain LSc 2ab (PV-1) can no longer be used for the evaluation of virucidal activity of chemical disinfectants. This study evaluated murine parvovirus ATCC VR 1346 (minute virus of mice) as suitable surrogate for PV-1 when testing virucidal activity of biocides in instrument and surface disinfectants. Suspension testing in different laboratories with two commercially available active biocidal substances based on glutaraldehyde (0.01-0.25%) and peracetic acid (0.005-0.1%) with an exposure time of 30 min was performed. Both pathogens showed comparable susceptibility and dose-dependent reduction of virus titres following German and European Guidelines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0ce0ac1c99442b66ee96ce15020c1d https://doi.org/10.1016/j.jhin.2021.12.022 Zobrazit plný text záznamu Full Text from ScienceDirect