Socioeconomic Differences in Referral to Phase I Cancer Clinical Trials: A Danish Matched Cancer Case-Control Study
| Autor: | Christoffer Johansen, Ulrik Lassen, Katrine Toubro Gad, Anne Katrine Duun-Henriksen, Morten Mau-Sørensen, S. O. Dalton, Maja Halgren Olsen, Anja Krøyer |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Referral Cancer clinical trial Registry study Denmark Danish 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms Journal Article medicine Humans 030212 general & internal medicine Registries Socioeconomic status Referral and Consultation Socioeconomic differences Aged Proportional Hazards Models Cancer case business.industry Research Support Non-U.S. Gov't Patient Selection Cancer Middle Aged medicine.disease language.human_language Oncology Socioeconomic Factors 030220 oncology & carcinogenesis Case-Control Studies language Female business |
| Zdroj: | Gad, K T, Johansen, C, Duun-Henriksen, A K, Krøyer, A, Olsen, M H, Lassen, U, Mau-Sørensen, M & Oksberg Dalton, S 2019, ' Socioeconomic Differences in Referral to Phase I Cancer Clinical Trials : A Danish Matched Cancer Case-Control Study ', Journal of Clinical Oncology, vol. 37, no. 13, pp. 1111-1119 . https://doi.org/10.1200/JCO.18.01983 |
| ISSN: | 1527-7755 |
| Popis: | PURPOSE In this nationwide registry study, we investigated socioeconomic and structural patterns in referral to phase I cancer trials in a case-control study design. METHODS Personal identification numbers on all Danish patients referred to the Danish Phase I Unit at Rigshospitalet from 2005 to 2016, and a control group matched on age, sex, type of cancer, year of diagnosis, and time from diagnosis to referral ensured individual-level linkage between several registries. We examined the association between nonclinical factors—indicators of socioeconomic position and distance to the Phase I Unit—and referral using a conditional logistic regression analysis adjusted for several clinical factors. Association between nonclinical factors and enrollment once referred was examined with a Cox proportional hazards regression analysis in an historical cohort study design. RESULTS Complete data were available for 1,026 (84%) of 1,220 referred patients. Significantly decreased odds for referral were identified for patients with long distance to the Phase I Unit compared with short distance (adjusted odds ratio [OR], 0.35; 95% CI, 0.30 to 0.41), for less education (less than 9 years) compared with more (more than 12 years; OR, 0.69; 95% CI, 0.56 to 0.91), and for belonging to the lowest income quintile compared with the highest (OR, 0.78; 95% CI, 0.62 to 0.97). Medium education (9 to 12 years) compared with more, being outside the workforce compared with being within, and living alone compared with living with a partner were also negatively associated with referral. Among patients referred, 252 enrolled in a trial. Nonclinical factors were not associated with enrollment. CONCLUSION On the basis of individual long-term registry data from an unselected cohort, novel anticancer therapies seem to be tested on a socially selected group of patients with cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|