Eating to dare - Nutrition impacts human risky decision and related brain function
| Autor: | Peter Mohr, Jeremy Tardu, Britta Wilms, Berthold Koletzko, Sergio Oroz Artigas, Lu Liu, Anja Ulrich, Sebastian M. Schmid, Soyoung Q. Park |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Food intake Plasma tryptophan Macronutrient Eating chemistry.chemical_compound 0302 clinical medicine Neurotransmitter chemistry.chemical_classification Fat mass 05 social sciences Tryptophan Brain Parietal lobule Magnetic Resonance Imaging Amino acid Adipose Tissue Neurology Risky decision-making Serotonin RC321-571 Adult medicine.medical_specialty Cognitive Neuroscience Decision Making Nutritional Status Neurosciences. Biological psychiatry. Neuropsychiatry Biology Individual risk 050105 experimental psychology Young Adult 03 medical and health sciences Risk-Taking Double-Blind Method Internal medicine Dietary Carbohydrates medicine Protein meal Humans 0501 psychology and cognitive sciences Brain function Inferior parietal lobule Feeding Behavior Nutrients Endocrinology chemistry 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage, 233:117951 NeuroImage, Vol 233, Iss, Pp 117951-(2021) |
| Popis: | Macronutrient composition modulates plasma amino acids that are precursors of neurotransmitters and can impact brain function and decisions. Neurotransmitter serotonin has been shown to regulate not only food intake, but also economic decisions. We investigated whether an acute nutrition-manipulation inducing plasma tryptophan fluctuation affects brain function, thereby affecting risky decisions. Breakfasts differing in carbohydrate/protein ratios were offered to test changes in risky decision making while metabolic and neural dynamics were tracked. We identified that a high-carbohydrate/protein meal increased plasma tryptophan which mapped to individual risk propensity changes. Moreover, the meal-driven fluctuation in tryptophan and risk propensity changes were modulated by individual difference in body fat mass. Using fMRI, we further identified activation in the parietal lobule during risk-processing, of which activities 1) were correlated with the risk propensity changes in decision making, 2) were sensitive to the tryptophan fluctuation, and 3) were modulated by individual’s body fat mass. Furthermore, the activity in the parietal lobule positively mediated the tryptophan-fluctuation to risk-propensity-changes relationship. Our results provide evidence for a personalized nutrition-driven modulation on human risky decisions and its metabolic and neural mechanisms. |
| Databáze: | OpenAIRE |
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