Does mechanical morcellation of large glands compromise incidental prostate cancer detection on specimen analysis? A pathological comparison with open simple prostatectomy
| Autor: | Nathalie Rioux-Leclercq, Romain Mathieu, Vincent Misrai, Benoit Bordier, Marie Pasquie, Virginie Guillotreau, Sébastien Kerever, Sébastien Vincendeau, Enrique Rijo, Eva-Maria Compérat, Julien Guillotreau, Benoit Peyronnet, R. Huet, Julien Palasse |
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| Přispěvatelé: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2018 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Histology Urethral Obstruction Urology medicine.medical_treatment Enucleation 030232 urology & nephrology Prostatic Hyperplasia [SDV.CAN]Life Sciences [q-bio]/Cancer Morcellation 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Internal medicine medicine Humans Pathological ComputingMilieux_MISCELLANEOUS Aged Neoplasm Staging Prostatectomy Incidental Findings business.industry Transurethral Resection of Prostate Prostatic Neoplasms Middle Aged medicine.disease Prostate-specific antigen medicine.anatomical_structure 030220 oncology & carcinogenesis Propensity score matching Laser Therapy Benign prostatic obstruction business |
| Zdroj: | World Journal of Urology World Journal of Urology, Springer Verlag, 2019, 37 (7), pp.1315-1320. ⟨10.1007/s00345-018-2532-z⟩ World Journal of Urology, 2019, 37 (7), pp.1315-1320. ⟨10.1007/s00345-018-2532-z⟩ |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-018-2532-z⟩ |
| Popis: | This study sought to compare the incidental prostate cancer (iPCa) detection rate between pathological specimens from green laser enucleation of the prostate (GreenLEP) and open simple prostatectomy (OSP). In two institutions, the charts of all consecutive patients who underwent OSP between January 2005 and December 2010 were retrospectively reviewed, and the data of all consecutive patients who underwent GreenLEP with tissue morcellation between July 2013 and January 2018 were also collected. Preoperative demographics and pathological findings were recorded. iPCa detection rate was retrospectively compared between the GreenLEP and OSP groups in a propensity score model, including all predetermined variables: Age, preoperative PSA level and prostate volume. Of 738 patients, 402 were included in the propensity-score matching analysis, and they were equally distributed among groups. The overall iPCa detection rates were similar in both groups (9.9% vs. 8.5%; p = 0.73), and there were no statistically significant differences in terms of tumour stage, Gleason score or the rate of clinically significant iPCa, although the number of cassettes analysed was significantly higher in the morcellation group than in the OSP group. No predictive factors for iPCa were identified. The results of the present study suggest that the mechanical morcellation of large glands had no influence on iPCa detection. Compared with a specimen from standard OSP, a large morcellated tissue sample allows adequate pathological evaluation and does not alter a pathologist’s ability to detect iPCa. |
| Databáze: | OpenAIRE |
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