Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
| Autor: | Donald J. Cohen, Barbara K. Caparulo, George M. Anderson, Mary Ellen Kavanagh, Sally E. Shaywitz, Jill Detlor, Young Jg, Hunt Rd, James F. Leckman, Bennett A. Shaywitz, Diane F. Harcherik |
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| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Developmental Disabilities Neurocognitive Disorders Child Behavior Disorders Tourette syndrome Methoxyhydroxyphenylglycol Catecholamines Neurochemical Interview Psychological medicine Child and adolescent psychiatry Humans Ethics Medical Pharmacological challenge Child Brain function Psychological Tests Informed Consent Research Pediatric research Homovanillic Acid Hydroxyindoleacetic Acid medicine.disease Psychiatry and Mental health Clinical research Motor Skills Autism Perception Psychology Clinical psychology |
| Zdroj: | Schizophrenia Bulletin. 8:205-235 |
| ISSN: | 1745-1701 0586-7614 |
| DOI: | 10.1093/schbul/8.2.205 |
| Popis: | Psychobiological research in child psychiatry requires rigorous assessment of behavior and multiple perspectives on brain function through neurochemical, neuroendocrine, psychophysiological, and other advanced methods. The serious neuropsychiatric disorders of childhood, such as autism, attention deficit disorder, and language disorders, can be studied in complementary clinical protocols aimed at explicating patterns of behavioral and metabolic dysfunction which characterize various clinical syndromes. Clinical research with children raises sensitive ethical issues; the ethical problems can be addressed when children and families are active collaborators with the investigators and a long-term relationship is established. In this setting, participation in research can facilitate better treatment for a child. The use of novel biological strategies, such as pharmacological challenge tests, permits evaluation of the relation of specific neuronal systems to behavioral dimensions in clinical disorders. The development of a new treatment for Tourette's syndrome illustrates the integration of basic and clinical research methods. |
| Databáze: | OpenAIRE |
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