Peripheral Arterial Stiffness Increases the Risk of Progression of Renal Disease in Type 2 Diabetic Patients
| Autor: | Hyoung Woo Lee, Seung Min Chung, Dong Sung Lee, Ji Sung Yoon, Se Ra Choi, Kyu Chang Won, Tae Hoon Lim, Jun Sung Moon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
pulse wave velocity 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology renal function decline Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Risk factor Pulse wave velocity Original Research lcsh:R5-920 business.industry diabetic nephropathy Retrospective cohort study General Medicine medicine.disease Blood pressure arterial stiffness diabetes mellitus Arterial stiffness Cardiology Medicine business lcsh:Medicine (General) |
| Zdroj: | Frontiers in Medicine, Vol 7 (2020) Frontiers in Medicine |
| Popis: | Aims: Our aim was to investigate the effects of peripheral arterial stiffness on the risk of progression of renal disease in patients with type 2 diabetes (T2D). Methods: This was a single center, retrospective cohort study. Brachial-ankle pulse wave velocity (baPWV) tests were performed on T2D patients in 2015. Increased arterial stiffness was defined as baPWV of ≥ 1800 cm/s. We applied criteria for progression of renal disease according to EMPA-REG OUTCOME trial. Results: In total, 186 patients were enrolled in the final study. The mean age was 59.1 years and male:female ratio was 1.73:1. Thirteen (7%) patients progressed to renal disease during the average follow-up time of 35.3 months. In particular, the risk of progression to macroalbuminuria was significantly higher in the baPWV ≥ 1800 cm/s group (HR 6.216, p = 0.020). Individuals with a baPWV of ≥ 1800 cm/s (when comparisons were adjusted for age, sex, blood pressure, diabetes duration, eGFR, and use of renin-angiotensin system inhibitors) had a significantly higher risk of the progression of renal disease (HR = 8.480, p = 0.014). Conclusion: These results suggest that peripheral arterial stiffness (baPWV ≥ 1800 cm/s) may be a risk factor for the progression of renal disease in T2D patients. |
| Databáze: | OpenAIRE |
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