Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut
| Autor: | Martin J. Somerville, Laura Arbour, Gwen Healey Akearok, Anders C. Erickson, Amber Miners, David M. Goldfarb, Sorcha A. Collins, Sharon Edmunds, J. Robert Thompson, Elske Hildes-Ripstein, Cheryl Rockman-Greenberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Breastfeeding Logistic regression RJ1-570 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Lower respiratory tract infection medicine Early childhood Socioeconomic status respiratory tract infection in children Respiratory tract infections business.industry medicine.disease Infant mortality Indigenous 030104 developmental biology Otitis Inuit p.P479L arctic variant Pediatrics Perinatology and Child Health infectious illness medicine.symptom carnitine palmitoyltransferase 1A business |
| Zdroj: | Frontiers in Pediatrics, Vol 9 (2021) |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2021.678553/full |
| Popis: | Objective: Infectious illness, including lower respiratory tract infection (LRTI), is a leading cause of childhood morbidity and infant mortality in Inuit children in Nunavut Canada. The carnitine palmitoyltransferase 1A (CPT1A) p.P479L variant is common in arctic Indigenous populations of Alaska, Canada, and Greenland. CPT1A is a fatty acid oxidation enzyme expressed in the liver, immunocytes and other tissues, and is needed to use fats for energy during fasting. Previous association of the variant with early childhood infectious illness and infant death has been challenged because of sample size and limited adjustment for confounders. We evaluated whether the p.P479L variant is associated with infectious illness in Inuit children of Nunavut, Canada.Methods: We conducted a retrospective clinical chart review of 2,225 Inuit children (0–5 years) for infectious illness (including otitis media, gastroenteritis, and hospital admission for LRTI), prenatal, perinatal, and socioeconomic indicators, subsequently linking to CPT1A genotype. Multivariable logistic regression adjusted for birth characteristics, breastfeeding, maternal smoking, food insecurity, and socioeconomic indicators.Results: Overall, 27% of children were hospitalized for LRTI, 86% had otitis media and 50% had gastroenteritis. The p.P479L allele frequency was 0.82. In multivariable analysis, p.P479L homozygosity was associated with LRTI admission (aOR:2.88 95%CI:1.46–5.64), otitis media (aOR:1.83, 95%CI:1.05–3.21), and gastroenteritis (aOR:1.74, 95%CI:1.09–2.77), compared to non-carriers.Conclusion: Children homozygous for the p.P479L variant were more likely to experience infectious illness than non-carriers, including hospitalization for respiratory tract infections. Given the role of CPT1A in immunocytes, our findings indicate that more study is needed to determine if there is a role of the variant in immune response. Continued Inuit involvement is essential when considering next steps. |
| Databáze: | OpenAIRE |
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