Potent benzimidazolone based human beta(3)-adrenergic receptor agonists

Autor:	Don Richard Finley, Mark A. Winter, Daniel Jon Sall, Mark L. Heiman, Marlene L. Cohen, Christopher John Rito, Tania Miles, Anthony J. Shuker, William E. Bloomquist, Anthony G. Borel, Thomas W. Stephens, Michael Gregory Bell, Cynthia Darshini Jesudason, Aidas Kriauciunas, Donald P. Matthews, David Andrew Neel, Frank C. Tinsley
Rok vydání:	2006
Předmět:	Beta-3 adrenergic receptor Agonist medicine.medical_specialty medicine.drug_class Clinical Biochemistry Pharmaceutical Science Carboxamide Biochemistry Chemical synthesis Beta-1 adrenergic receptor Internal medicine Drug Discovery medicine Moiety Humans cardiovascular diseases Beta (finance) Molecular Biology Chemistry Organic Chemistry Adrenergic beta-Agonists In vitro Endocrinology cardiovascular system Molecular Medicine Benzimidazoles Adrenergic beta-3 Receptor Antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 16(21)
ISSN:	0960-894X
Popis:	The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafcd2d226d8437bcf2e7a738cbeb735 https://pubmed.ncbi.nlm.nih.gov/16931005 Zobrazit plný text záznamu Full Text from ScienceDirect