Pancreaticobiliary juice releases motilin during phase I of the migrating motor complex in man
| Autor: | Per M. Hellström, G. Hedenborg, I. M. Modlin, Elvar Theodorsson, I. Nilsson, T. Svenberg |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Duodenum medicine.medical_treatment Peptide hormone Pancreatic Polypeptide Gastroenterology Motilin Pancreatic Juice Internal medicine Gastrins medicine Humans Peptide YY Saline Migrating motor complex Myoelectric Complex Migrating Chemistry digestive oral and skin physiology Perfusion Endocrinology medicine.anatomical_structure Pancreatic juice Peptides |
| Zdroj: | Scandinavian journal of gastroenterology. 28(1) |
| ISSN: | 0036-5521 |
| Popis: | The effect of duodenal perfusion with pancreaticobiliary juice on plasma motilin was investigated in eight fasting subjects. The study was undertaken with recording of gastrointestinal motility, to predict spontaneous fluctuations in plasma motilin levels. Duodenal perfusion with pancreaticobiliary juice or saline at a rate of 5 ml/min for 10 min was performed in random order after the second or third activity front. The 30-min integrated plasma motilin response was significantly greater after perfusion with pancreaticobiliary juice: 1.5 (0.7-2.3) nmol x min/l (mean and 95% confidence interval), compared with 1.0 (0.5-1.5) nmol x min/l after saline (p < 0.05). Although perfusion with pancreaticobiliary juice was followed by endogenous plasma motilin peaks after about 20 min in six of eight subjects, the mean interval to the next activity front was not significantly different. In conclusion, duodenal perfusion with pancreaticobiliary juice in phase I of the migrating motor complex releases plasma motilin without affecting the fasting motility pattern. |
| Databáze: | OpenAIRE |
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