Sudden cardiac death in anabolic androgenic steroids abuse: case report and literature review
| Autor: | Javier Tapia, Ana Isabel Hernández-Guerra, Joaquín Lucena, Luis Manuel Menéndez-Quintanal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Forensic pathology
Cardiac pathology Physiology Poison control Autopsy Case Reports Biochemistry Genetics and Molecular Biology (miscellaneous) sudden cardiac death Pathology and Forensic Medicine Analytical Chemistry Sudden cardiac death autopsy medicine cardiac pathology Physical and Theoretical Chemistry lcsh:K5000-5582 Adverse effect anabolic androgenic steroids (AAS) business.industry lcsh:Public aspects of medicine Androgenic steroids lcsh:RA1-1270 forensic pathology medicine.disease Anabolic-androgenic steroids abuse Psychiatry and Mental health Anthropology lcsh:Criminal law and procedure Forensic sciences business toxicology |
| Zdroj: | Forensic Sciences Research Forensic Sciences Research, Vol 4, Iss 3, Pp 267-273 (2019) |
| ISSN: | 2471-1411 2096-1790 |
| Popis: | Anabolic androgenic steroids (AAS) have several adverse effects on the cardiovascular system that may lead to a sudden cardiac death (SCD). We herein report a case involving a 24-year-old male, AAS abuser with intramuscular delivery in the 6 months before, who suffered a cardiorespiratory arrest at home’s bathtub when returning from New Year’s party. A forensic autopsy was performed according to the guidelines of the Association for European Cardiovascular Pathology (AECVP). The body showed hypertrophy of skeletal musculature, with low amount of subcutaneous fat and no signs of injury (body mass index, BMI: 26.8 kg/m2). On internal examination, there were multiorgan congestion, acute pulmonary edema, and cardiomegaly (420 g) with severe coronary atherosclerosis and superimposed acute occlusive thrombosis at the left main trunk and left anterior descendant. Areas of scarring were located at the intersection between the posterior wall and the posterior third of the septum (postero-septal). At histology, acute myocardial infarction at the anterior third of the septum and the anterior wall, and subacute myocardial infarction at apical septum and apical posterior wall were detected. Other findings were small intramyocardial vessel disease and myocytes hypertrophy. Chemicotoxicological analysis in blood showed ethanol ((0.90 ± 0.05) g/L), stanazolol (11.31 µg/L), nandrolone (2.05 µg/L) and testosterone ( |
| Databáze: | OpenAIRE |
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