The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants
| Autor: | Luis García de Guadiana-Romualdo, Ana Hernando-Holgado, Carmen Fuentes-Gutiérrez, Ana García-González, Enrique Jiménez-Santos, José Luis Leante-Castellanos |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Late onset Gastroenterology Reference Values Sepsis Internal medicine Humans Infant Very Low Birth Weight Medicine Prospective Studies Prospective cohort study Membrane Glycoproteins Receiver operating characteristic biology Neonatal sepsis business.industry Obstetrics Infant Newborn Area under the curve Obstetrics and Gynecology medicine.disease Predictive value Low birth weight Pediatrics Perinatology and Child Health biology.protein bacteria Female medicine.symptom Carrier Proteins business Lipopolysaccharide binding protein Acute-Phase Proteins |
| Zdroj: | Journal of Perinatal Medicine. 43:253-257 |
| ISSN: | 1619-3997 0300-5577 |
| Popis: | Objective: To assess the accuracy of lipopolysaccharide binding protein (LBP) for diagnosing late-onset neonatal sepsis (LONS) in very low birth weight (VLBW) infants. Study design: Observational, prospective study. We assessed the diagnostic performance of LBP in 26 suspected LONS episodes among 54 patients. Proven and probable LONS episodes were recorded according to established criteria. Receiver operating characteristic curve analysis was performed to evaluate LBP’s ability to predict LONS. Results: LONS was diagnosed in 17 of 26 episodes. LBP levels were significantly higher in confirmed LONS episodes (P Conclusions: Serum LBP measurement may be useful as an additional tool in the evaluation of suspected LONS in VLBW infants. |
| Databáze: | OpenAIRE |
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