Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
| Autor: | Maria Victoria Olmedo-Gaya, Candelaria Reyes-Botella, Enrique García-Recio, Concepción Ruiz, Víctor J. Costela-Ruiz, Francisco Javier Manzano-Moreno |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Saliva
diagnosis Oral pathology Review chemistry.chemical_compound Salivary biomarker Diagnosis Medicine RNA Neoplasm Biology (General) Salivary biomarkers Spectroscopy microRNA Oral cancer MicroRNA General Medicine Prognosis Neoplasm Proteins Computer Science Applications Chemistry Cytokines Mouth Neoplasms oral pathology QH301-705.5 Extracellular vesicles Catalysis Inorganic Chemistry Oral and maxillofacial pathology Biomarkers Tumor Humans Basal cell Salivary Proteins and Peptides Physical and Theoretical Chemistry Molecular Biology QD1-999 Squamous Cell Carcinoma of Head and Neck business.industry Organic Chemistry RNA oral cancer medicine.disease cytokines MicroRNAs stomatognathic diseases salivary biomarker chemistry Cancer research business DNA |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 12215, p 12215 (2021) Digibug. Repositorio Institucional de la Universidad de Granada instname International Journal of Molecular Sciences |
| Popis: | This study was supported by research group BIO277 (Junta de Andalucia), Department of Nursing (University of Granada) and Department of Stomatology (University of Granada) Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs. BIO277 (Junta de Andalucia), Department of Nursing (University of Granada) Department of Stomatology (University of Granada) BIO277 |
| Databáze: | OpenAIRE |
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