Emerging roles of extracellular vesicles in cardiac repair and rejuvenation
| Autor: | Faisal J. Alibhai, Stephanie W. Tobin, Ren-Ke Li, Richard D. Weisel, Azadeh Yeganeh |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cardiac function curve Physiology Bioinformatics Extracellular vesicles Cell therapy Extracellular Vesicles 03 medical and health sciences Therapeutic approach Physiology (medical) medicine Animals Humans Regeneration Myocardial infarction Beneficial effects Rejuvenation business.industry Myocardium Heart medicine.disease 3. Good health 030104 developmental biology Cardiac repair cardiovascular system Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 315:H733-H744 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00100.2018 |
| Popis: | Cell therapy has received significant attention as a therapeutic approach to restore cardiac function after myocardial infarction. Accumulating evidence supports that beneficial effects observed with cell therapy are due to paracrine secretion of multiple factors from transplanted cells, which alter the tissue microenvironment and orchestrate cardiac repair processes. Of these paracrine factors, extracellular vesicles (EVs) have emerged as a key effector of cell therapy. EVs regulate cellular function through the transfer of cargo, such as microRNAs and proteins, which act on multiple biological pathways within recipient cells. These discoveries have led to the development of cell-free therapies using EVs to improve cardiac repair after a myocardial infarction. Here, we present an overview of the current use of EVs to enhance cardiac repair after myocardial infarction. We also discuss the emerging use of EVs for rejuvenation-based therapies. Finally, future directions for the use of EVs as therapeutic agents for cardiac regenerative medicine are also discussed. |
| Databáze: | OpenAIRE |
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