Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole
| Autor: | Manikandan Kadirvel, Sally Freeman, Gavin Brown, Déborah Cardoso |
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| Přispěvatelé: | Brown, Gavin [0000-0003-4443-0785], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Health
Toxicology and Mutagenesis Methyl isocyanate 010402 general chemistry 01 natural sciences Medicinal chemistry Article Analytical Chemistry chemistry.chemical_compound Radiology Nuclear Medicine and imaging Reactivity (chemistry) Chemical route Spectroscopy 11C Radiochemistry 010405 organic chemistry Radiosynthesis Synthon Public Health Environmental and Occupational Health Pet imaging Pollution 0104 chemical sciences PET Nuclear Energy and Engineering chemistry Yield (chemistry) Carbamoylation Methyl iodide |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Kadirvel, M, Cardoso, D, Freeman, S & Brown, G 2018, ' Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole ', Journal of Radioanalytical and Nuclear Chemistry, vol. 317, no. 2 . https://doi.org/10.1007/s10967-018-5948-4 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-018-5948-4 |
| Popis: | N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions. Electronic supplementary material The online version of this article (10.1007/s10967-018-5948-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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