Case report: rheumatoid arthritis and large granular lymphocytes syndrome
| Autor: | R. Capra, Antonio Marchesoni, F. Galbiati, M. Arreghini, Francesca Ingegnoli, P. Bonara, B. Panni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty lcsh:Internal medicine Population lcsh:Medicine chemical and pharmacologic phenomena Neutropenia Rheumatology Medicine Rheumatoid factor Cytotoxic T cell Humans education lcsh:RC31-1245 education.field_of_study business.industry lcsh:R Middle Aged medicine.disease Leukemia Lymphoid medicine.anatomical_structure Rheumatoid arthritis Immunology Felty Syndrome Female Bone marrow business Complication CD8 |
| Zdroj: | Reumatismo, Vol 54, Iss 4 (2002) |
| ISSN: | 2240-2683 0048-7449 |
| Popis: | Felty’s syndrome (FS) is a rare complication (less than 1%) of rheumatoid arthritis (RA), with the clinical feature of splenomegaly and neutropenia. Approximately 10-40% of FS patients have an expansion of peripheral blood large granular lymphocytes (LGL). This cell population mainly consists of two subsets: cytotoxic T cells (CD8+, CD57+) and natural killer cells (CD3-,CD8-,CD56+). It has been hypothesised that LGL expansion could be responsible for neutropenia by suppressing neutrophil precursors in the bone marrow, but various mechanisms have been proposed to explain this association. We report a case of a 60-year-old woman with rheumatoid factor positive RA who developed LGL expansion responsible for splenomegaly, but without neutropenia. In conclusion, LGL expansion is an uncommon complication of RA and may be responsible for both FS and clinical pictures resembling FS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|