Ação antimitótica e antimutagênica do ritidoma de Hymenaea stigonocarpa Mart ex Hayne na divisão celular
| Autor: | Paulo Michel Pinheiro Ferreira, Maria do Socorro Meireles de Deus, João Marcelo de Castro e Sousa, G. M. Santana, Ana Paula Peron, H. B. Fernandes |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Time Factors 01 natural sciences Toxicology lcsh:Botany Onions lcsh:Zoology Hymenaea lcsh:QL1-991 lcsh:Science protector effect lcsh:QH301-705.5 Aqueous solution biology Cell Cycle lcsh:QK1-989 Distilled water visual_art Plant Bark visual_art.visual_art_medium cytotoxicity Bark General Agricultural and Biological Sciences medicine.drug Antipyretics food.ingredient Mitotic index Meristem Antimitotic Agents efeito protetor 03 medical and health sciences food jatobá-do-cerrado Mitotic Index medicine Antipyretic Acetaminophen Chromatography Plant Extracts citotoxicidade biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry 030104 developmental biology lcsh:Biology (General) lcsh:Q Hymenaea stigonocarpa Mutagens |
| Zdroj: | Brazilian Journal of Biology, Volume: 76, Issue: 2, Pages: 520-525, Published: 05 APR 2016 Brazilian Journal of Biology, Vol 76, Iss 2, Pp 520-525 Brazilian Journal of Biology v.76 n.2 2016 Brazilian Journal of Biology Instituto Internacional de Ecologia (IIE) instacron:IIE |
| ISSN: | 1678-4375 1519-6984 |
| DOI: | 10.1590/1519-6984.23014 |
| Popis: | The objective of this study was to evaluate the action of Hymenaea stigonocarpa bark hydroalcoholic extract against a mutagenic compound using A. cepa meristematic root cells as a test system. The treatment groups were: Negative Control (NC) – distilled water; Positive Control (PC) – paracetamol at a concentration of 0.008 mg/mL, Jatoba Control (JC) – aqueous fraction jatobá-do-cerrado at 0.5 or 1.0 or 1.5 mg/mL, and Simultaneous Treatment (ST) - jatobá-do-cerrado aqueous fraction at a concentration of 0.5 or 1.0 or 1.5 mg/mL associated with paracetamol solution at a concentration of 0.008 mg/mL. All groups were analyzed at 24 and 48 h. Five onion bulbs (five replications) were used for each treatment group. The root tips were fixed in Carnoy and slides prepared by the crush technique. Cells were analyzed throughout the cell cycle, totaling 5,000 for each treatment group at each exposure time. Mitotic indices were subjected to statistical analysis using the chi-square test (p |
| Databáze: | OpenAIRE |
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