Evidence for determining parasitic factors in addition to host genetics and immune status in the outcome of murine Leishmania infantum visceral leishmaniasis
| Autor: | Stéphanie Honore, Jean-Pierre Gangneux, Francis Derouin, Y. J. F. Garin, Annie Sulahian, Pascale Meneceur |
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| Rok vydání: | 2000 |
| Předmět: |
Mice
Inbred BALB C biology Host (biology) Immunology Congenic Virulence Mice SCID biology.organism_classification medicine.disease Leishmania Virology Disease Models Animal Mice Visceral leishmaniasis Immunity parasitic diseases medicine Animals Leishmaniasis Visceral Parasite hosting Female Parasitology Leishmania infantum |
| Zdroj: | Parasite Immunology. 22:515-519 |
| ISSN: | 1365-3024 0141-9838 |
| DOI: | 10.1046/j.1365-3024.2000.00332.x |
| Popis: | C.B-17 SCID and congenic BALB/C mice were used to examine Leishmania infantum strain pathogenicity independently of host genetic factors. While parasite loads were significantly higher in immunodeficient mice than in immunocompetent mice, the kinetics of infection during a long-term follow-up were similar, suggesting that intrinsic parasitic factors also influence the outcome of L. infantum infection. |
| Databáze: | OpenAIRE |
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