Transepithelial Leak in Barrett’s Esophagus
| Autor: | P. D. Allegretti, S. Trembeth, J. J. Verrecchio, Jon Meddings, James J Thornton, Mary Carmen Valenzano, Giancarlo Mercogliano, James M. Mullin, V. Jain, J. D. Schmidt |
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| Rok vydání: | 2006 |
| Předmět: |
Sucrose
medicine.medical_specialty Cell Membrane Permeability Physiology Biopsy digestive system Asymptomatic Gastroenterology Tight Junctions Barrett Esophagus Esophagus Internal medicine Metaplasia Claudin-1 medicine Claudin-3 Humans Claudin-5 Claudin Chemistry Esophageal disease Membrane Proteins Epithelial Cells medicine.disease digestive system diseases medicine.anatomical_structure Case-Control Studies Barrett's esophagus Amylases Claudins GERD medicine.symptom Esophagitis |
| Zdroj: | Digestive Diseases and Sciences. 51:2326-2336 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers. |
| Databáze: | OpenAIRE |
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