Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects
| Autor: | Lucia Račková, Magdalena Majekova, Milan Stefek, Daniela Košt’álová |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Jatrorrhizine
Antioxidant Time Factors DPPH medicine.medical_treatment Clinical Biochemistry Mahonia Pharmaceutical Science Hydroxylation Biochemistry Antioxidants Lipid peroxidation chemistry.chemical_compound Structure-Activity Relationship Berberine Alkaloids Phenols Drug Discovery medicine Organic chemistry Molecular Biology biology Plant Extracts Organic Chemistry biology.organism_classification chemistry Lipophilicity Liposomes Phosphatidylcholines Molecular Medicine Trolox Lipid Peroxidation Mitosporic Fungi Carbolines Hydrogen |
| Zdroj: | Bioorganicmedicinal chemistry. 12(17) |
| ISSN: | 0968-0896 |
| Popis: | The antioxidant activities of three alkaloids isolated from Mahonia aquifolium--berberine, jatrorrhizine, and magnoflorine--were studied with respect to their structural aspects, particularly the presence and the position of -OH groups, steric conditions of unpaired electron delocalization and parameters of lipophilicity and hydration energy. The antiradical activities of the compounds tested were evaluated as the reactivities toward free stable alpha,alpha'-diphenyl-beta-picrylhydrazyl radical (DPPH). The antioxidant features of the alkaloids tested were investigated in heterogeneous membrane system of DOPC liposomes stressed by peroxidative damage induced by AAPH azoinitiator. Both alkaloids bearing free phenolic groups--jatrorrhizine and magnoflorine--showed better activities in both systems used than berberine not bearing any readily abstractable hydrogen on its skeleton. The former two showed antiperoxidative efficiency in DOPC liposomal membrane comparable to that of an effective scavenger of peroxyl radicals--stobadine-and higher than that of Trolox. We conclude that the favorable antioxidant features of the hydroxylated alkaloids are most probably ensured by the combination of reasonably high antiradical reactivity with high lipophilicity, however, the solvation process was found to markedly interfere with these beneficial effects. |
| Databáze: | OpenAIRE |
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