Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition—retro-Mannich domino reaction

Autor:	Chiara Pizzo, Cecilia Saiz, Mary Liang, Peter Wipf
Rok vydání:	2009
Předmět:	Decarboxylation Thiophenol Organic Chemistry Biochemistry Combinatorial chemistry Article Cycloaddition chemistry.chemical_compound Diazepine Cascade reaction chemistry Drug Discovery Microwave irradiation Organic chemistry
Zdroj:	Tetrahedron Letters. 50:6810-6813
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.09.107
Popis:	Microwave irradiation facilitated the synthesis of 4-arylthio-3-oxazolin-5-ones from ethyl cyanoformate, thiophenol, and cyclic ketones. Subsequent decarboxylation and in situ [3+2] cycloaddition provided novel 2,3,4,5-tetrahydro-1H-pyrrolo[1,2-c][1,3]diazepine scaffolds after a spontaneous retro-Mannich domino reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf2efc28d989fa7c5463da5d3becf74 https://doi.org/10.1016/j.tetlet.2009.09.107 Zobrazit plný text záznamu Full Text from ScienceDirect